apalutamide will lower the level or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicine which are CYP2C19 substrates can result in decreased publicity to those medicines.diazepam increases levels of lomitapide by impacting he